Remember https://cnsnnts.wordpress.com/2023/11/26/runnings-impact-on-hdl-ldl/

There is research backing that. Similar to that, I have more research here. This shows that 4 to 5 days of exercise reverses everything!

https://twitter.com/tjthomps/status/1889056410941665775?s=46

https://journals.lww.com/acsm-essr/fulltext/2025/01000/aerobic_exercise_training_for_the_aging_brain_.5.aspx

https://pmc.ncbi.nlm.nih.gov/articles/PMC4272199/

Impact of Lifelong Exercise “Dose” on Left Ventricular Compliance and Distensibility

Paul S Bhella ^*,†, Jeffrey L Hastings ^†, Naoki Fujimoto ^†, Shigeki Shibata ^†, Graeme Carrick-Ranson ^†, Beverley Adams-Huet ^‡, Benjamin D Levine ^†,‡

• Author information
• Copyright and License information

PMCID: PMC4272199  NIHMSID: NIHMS615846  PMID: 25236519

The publisher’s version of this article is available at J Am Coll Cardiol

Abstract

Background

Sedentary aging has deleterious effects on the cardiovascular system, including decreased left ventricular compliance and distensibility (LVCD). Conversely, Masters level athletes, who train intensively throughout adulthood, retain youthful LVCD.

Objectives

To test the hypothesis that preservation of LVCD may be possible with moderate lifelong exercise training.

Methods

Healthy seniors (n = 102) were recruited from predefined populations, screened for lifelong patterns of exercise training, and stratified into 4 groups: “sedentary” (<2 sessions/week); “casual” (2 to 3 sessions/week); “committed” (4 to 5 sessions/week); and “competitive” Masters level athletes (6 to 7 sessions/week). Right heart catheterization and echocardiography were performed while preload was manipulated using lower body negative pressure and rapid saline infusion to define LV pressure–volume relationships and Frank-Starling curves.

Results

Peak oxygen uptake and LV mass increased with escalating doses of lifelong exercise, with little change in systolic function. At baseline, LV distensibility was greater in committed (21%) and competitive (36%) exercisers than in sedentary subjects. Group LV stiffness constants (sedentary: 0.062 ± 0.039; casual: 0.079 ± 0.052; committed: 0.055 ± 0.033; and competitive: 0.035 ± 0.033) revealed 1) increased stiffness in sedentary subjects compared to competitive athletes, whereas lifelong casual exercise had no effect; and 2) greater compliance in committed” exercisers than in sedentary or casual exercisers.

Conclusions

Low doses of casual, lifelong exercise do not prevent the decreased compliance and distensibility observed with healthy, sedentary aging. In contrast, 4 to 5 exercise sessions/week throughout adulthood prevent most of these age-related changes. As LV stiffening has been implicated in the pathophysiology of many cardiovascular conditions affecting the elderly, this “dose” of exercise training may have important implications for prevention of cardiovascular disease.

Keywords: aging, diastolic function, distensibility, exercise training, hemodynamics, ventricular compliance